Like the human-spawned Xenomorphs, the Destroyers have a skeletal, biomechanical appearance. They also have a few set of dorsal tubes and a flat ridge of spines located on their backs. They have a large body size and great physical strength, having been shown to be capable of leveling the ancient city and crushing its human-spawned brethren with little effort. Instead of having segmented tails, the Destroyers have a ridged tail with a set of tubes on each ridge, though they still have the blade at the tip of the tail.
Like other Xenomorphs, they have elongated, cylindrical skulls with no visible eyes and possess "inner jaws." They also incorporated several traits taken from their host, such as, through the appearance of the latest Destroyer that was born, are colored in brown, similar to the Space Jockey and possess the trunk located in the middle of the mouth coming from the nasal area to the chin area, though the trunk is not attached and becomes separated when the Destroyer opens its mouth.
According to Dr. Lucien Keitel, the Xenomorphs first appeared one and one-half billion years ago to exterminate the Space Jockeys as they have become the most dominant race in the galaxy at the time. Through the use of the Space Jockeys as hosts, the Destroyers were born and eventually succeeded in exterminating the Space Jockeys, therefore restoring balance in the galaxy. Many years later, another Destroyer was born after the Synthetic, Baal who assisted Alecto Throop during her expedition to find Dr. Keitel in the ancient city became infected with Weyland-Yutani's subversion programming and under the programming's influence planted an egg near the last known living Space Jockey. A facehugger emerged from the egg and attaches itself to the Space Jockey that was barely living, creating the Destroyer. The Destroyer crushed Baal and began to wreak havoc in the ancient city, killing its own human-spawned brethren and causing the ancient city to cave in. The Destroyer later makes its last appearance as an unlikely hero. When Alecto and her remaining crew are escaping the ancient city aboard the Rachel, a Xenomorph snuck aboard the ship. As the Xenomorph prepares to attack, the Destroyer grabs the Xenomorph through the bay, allowing Alecto and her crew to escape.