A flamethrower was used by the crew of the USCSS Prometheus during the exploration of LV-223.

One is used by Vickers to kill Holloway after he had been infected with the black liquid. One is also later used by a mercenary to try and kill the infected Fifield in the Prometheus' hangar when Fifield begins running rampant in the hangar and killing the crew (although it proved ineffective) and another is shortly later by Janek to torch the mutated Fifield in the Prometheus' hangar after Fifield had been crushed by the wheels of an RT-01 Transport.