On arrival the USS Sephora docks alongside the USS Sulaco. The Sephora's marines are investigating the Sulaco in teams while a Xenomorph infestation is occuring aboard the Sulaco.
In the level Battle for Sulaco the Sephora was destroyed after the Sulaco weapon systems were activated by Weyland-Yutani PMC soldiers, first exploding then finally crashing to the surface of LV-426 along with the Sulaco in the level Sulaco Falls.
- Captain Cruz - A19/TQ4.0.32751E8
- Corporal Winter - A09/TQ4.0.56124E3
- Private O'Neal - A27/TQ4.0.48215E9
- Private Bella - A03/TQ7.0.15618E4
- Lieutenant Reid - A71/TQ9.0.09428E1
- Private Keyes
- In Aliens: Colonial Marines gameplay the Sulaco and Sephora can be seen burning on the surface not far from Hadley's Hope in the level No Hope in Hadley's.
- In Aliens: Infestation the Sulaco and Sephora are also in orbit around LV-426 but the spacecrafts survive the campaigns.
- In Aliens: Infestation a different squad is sent to the surface then in Aliens: Colonial Marines with a player being able to choose one of nineteen marines making up part of Six-one squad with help from Fox-six squad.